Evidence that pericytes regulate aquaporin-4 polarization in mouse cortical astrocytes
نویسندگان
چکیده
منابع مشابه
Human and mouse cortical astrocytes differ in aquaporin‐4 polarization toward microvessels
Aquaporin-4 (AQP4), the predominant water channel in the brain, is expressed in astrocytes and ependymal cells. In rodents AQP4 is highly polarized to perivascular astrocytic endfeet and loss of AQP4 polarization is associated with disease. The present study was undertaken to compare the expression pattern of AQP4 in human and mouse cortical astrocytes. Cortical tissue specimens were sampled fr...
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Human aquaporin 4 (AQP4) is the primary water channel protein in brain astrocytes. Hypothermia is known to cause astrocyte swelling in culture, but the precise role of AQP4 in this process is unknown. Primary human cortical astrocytes were cultured under hypothermic (32 °C) or normothermic (37 °C) conditions. AQP4 transcript, total protein and surface-localized protein were quantified using RT-...
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ژورنال
عنوان ژورنال: Brain Structure and Function
سال: 2013
ISSN: 1863-2653,1863-2661
DOI: 10.1007/s00429-013-0629-0